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. 2015 Sep 30;20(10):18001-15.
doi: 10.3390/molecules201018001.

Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad

Rachid Chawech  1   2   3 , Raoudha Jarraya  4 , Cynthia Girardi  5   6 , Marieke Vansteelandt  7   8 , Guillaume Marti  9   10 , Imen Nasri  11   12 , Claire Racaud-Sultan  12 , Nicolas Fabre  13   14
Affiliations

Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad

Rachid Chawech et al. Molecules. .

Abstract

Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines.

Keywords: Citrullus colocynthis; cucurbitacins; cytotoxicity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of compounds 1–6.
Figure 2
Figure 2
Key COSY (thick bonds), HMBC (solid arrows) and NOESY (dashed arrows) correlations of compounds 1 and 2.
Figure 3
Figure 3
Log-dose response and EC50 of compounds 1, 2 and 6.
See this image and copyright information in PMC

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