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Review
. 2015 Sep 30;6(4):957-76.
doi: 10.3390/genes6040957.

Impact of Chromatin on HIV Replication

Luis M Agosto  1 , Matthew Gagne  2 , Andrew J Henderson  3   4
Affiliations
Review

Impact of Chromatin on HIV Replication

Luis M Agosto et al. Genes (Basel). .

Abstract

Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated factors to reduce the HIV proviral load are discussed.

Keywords: HIV; chromatin; integration; latency; transcription.

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Figures

Figure 1
Figure 1
General regulation of HIV transcription and chromatin remodeling. Cellular transcription factors (e.g., p50/p65 NF-κB heterodimers) recognize motifs within the HIV provirus promoter region and recruit cellular co-activators, chromatin remodeling factors and transcription elongation factors. Negative transcription factors (e.g., p50/p50 NF-κB homodimers) recruit cellular co-repressors, chromatin remodeling factors and factors that hinder transcription elongation.
See this image and copyright information in PMC

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