The Functions of MicroRNAs: mRNA Decay and Translational Repression

doi:10.1016/j.tcb.2015.07.011

Review

. 2015 Nov;25(11):651-665.

doi: 10.1016/j.tcb.2015.07.011. Epub 2015 Oct 1.

The Functions of MicroRNAs: mRNA Decay and Translational Repression

Hiro-Oki Iwakawa¹, Yukihide Tomari²

Affiliations

¹ Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
² Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: tomari@iam.u-tokyo.ac.jp.

PMID: 26437588
DOI: 10.1016/j.tcb.2015.07.011

Review

The Functions of MicroRNAs: mRNA Decay and Translational Repression

Hiro-Oki Iwakawa et al. Trends Cell Biol. 2015 Nov.

. 2015 Nov;25(11):651-665.

doi: 10.1016/j.tcb.2015.07.011. Epub 2015 Oct 1.

Authors

Hiro-Oki Iwakawa¹, Yukihide Tomari²

Affiliations

¹ Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
² Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: tomari@iam.u-tokyo.ac.jp.

PMID: 26437588
DOI: 10.1016/j.tcb.2015.07.011

Abstract

MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs, which regulate complementary mRNAs by inducing translational repression and mRNA decay. Although this dual repression system seems to operate in both animals and plants, genetic and biochemical studies suggest that the mechanism underlying the miRNA-mediated silencing is different in the two kingdoms. Here, we review the recent progress in our understanding of how miRNAs mediate translational repression and mRNA decay, and discuss the contributions of the two silencing modes to the overall silencing effect in both kingdoms.

Keywords: AGO; Argonaute; RISC; RNA silencing; miRNA; plant.

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The Functions of MicroRNAs: mRNA Decay and Translational Repression

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The Functions of MicroRNAs: mRNA Decay and Translational Repression

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