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. 2016 Apr;20(4):870-9.
doi: 10.1007/s10461-015-1213-9.

Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya

Ann E Kurth  1 , Charles M Cleland  2 , Nok Chhun  2 , John E Sidle  3 , Edwin Were  4   5 , Violet Naanyu  6   5 , Wilfred Emonyi  7   5 , Stephen M Macharia  8   5 , Edwin Sang  5 , Abraham M Siika  9   5
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Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya

Ann E Kurth et al. AIDS Behav. 2016 Apr.

Abstract

We evaluated performance, accuracy, and acceptability parameters of unsupervised oral fluid (OF) HIV self-testing (HIVST) in a general population in western Kenya. In a prospective validation design, we enrolled 240 adults to perform rapid OF HIVST and compared results to staff administered OF and rapid fingerstick tests. All reactive, discrepant, and a proportion of negative results were confirmed with lab ELISA. Twenty participants were video-recorded conducting self-testing. All participants completed a staff administered survey before and after HIVST to assess attitudes towards OF HIVST acceptability. HIV prevalence was 14.6 %. Thirty-six of the 239 HIVSTs were invalid (15.1 %; 95 % CI 11.1-20.1 %), with males twice as likely to have invalid results as females. HIVST sensitivity was 89.7 % (95 % CI 73-98 %) and specificity was 98 % (95 % CI 89-99 %). Although sensitivity was somewhat lower than expected, there is clear interest in, and high acceptability (94 %) of OF HIV self-testing.

Keywords: HIV; Oral fluid; Self-testing; Sensitivity; Specificity.

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References

    1. Menzies N, Abang B, Wanyenze R, et al. The costs and effectiveness of four HIV counseling and testing strategies in Uganda. Aids. 2009;23(3):395–401. doi: 10.1097/QAD.0b013e328321e40b. - DOI - PubMed
    1. Sweat M, Gregorich S, Sangiwa G, et al. Cost-effectiveness of voluntary HIV-1 counselling and testing in reducing sexual transmission of HIV-1 in Kenya and Tanzania. Lancet. 2000;356(9224):113–121. doi: 10.1016/S0140-6736(00)02447-8. - DOI - PubMed
    1. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009;373(9657):48–57. doi: 10.1016/S0140-6736(08)61697-9. - DOI - PubMed
    1. WHO. Towards universal access: scaling up priorities HIV/AIDS interventions in the health sector: progress report. 2010. Available at http://whqlibdoc.who.int/publications/2010/9789241500395_eng.pdf. Accessed 12 Nov 2014.
    1. UNAIDS. The Gap Report. 2014. Available at http://www.unaids.org/sites/default/files/media_asset/UNAIDS_Gap_report_.... Accessed 5 Jan 2015.

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