Consensus Paper: Cerebellar Development

Ketty Leto^{1

2}, Marife Arancillo³, Esther B E Becker⁴, Annalisa Buffo^{5

6}, Chin Chiang⁷, Baojin Ding⁸, William B Dobyns^{9

10}, Isabelle Dusart^{11

12}, Parthiv Haldipur⁹, Mary E Hatten¹³, Mikio Hoshino¹⁴, Alexandra L Joyner¹⁵, Masanobu Kano¹⁶, Daniel L Kilpatrick⁸, Noriyuki Koibuchi¹⁷, Silvia Marino¹⁸, Salvador Martinez¹⁹, Kathleen J Millen⁹, Thomas O Millner¹⁸, Takaki Miyata²⁰, Elena Parmigiani^{5

6}, Karl Schilling²¹, Gabriella Sekerková²², Roy V Sillitoe³, Constantino Sotelo²³, Naofumi Uesaka¹⁶, Annika Wefers²⁴, Richard J T Wingate²⁵, Richard Hawkes²⁶

Affiliations

¹ Department of Neuroscience Rita Levi Montalcini, University of Turin, via Cherasco 15, 10026, Turin, Italy. ketty.leto@unito.it.
² Neuroscience Institute Cavalieri-Ottolenghi, University of Turin, Regione Gonzole 10, 10043, Orbassano, Torino, Italy. ketty.leto@unito.it.
³ Departments of Pathology & Immunology and Neuroscience, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX, 77030, USA.
⁴ Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
⁵ Department of Neuroscience Rita Levi Montalcini, University of Turin, via Cherasco 15, 10026, Turin, Italy.
⁶ Neuroscience Institute Cavalieri-Ottolenghi, University of Turin, Regione Gonzole 10, 10043, Orbassano, Torino, Italy.
⁷ Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4114 MRB III, Nashville, TN, 37232, USA.
⁸ Department of Microbiology and Physiological Systems and Program in Neuroscience, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605-2324, USA.
⁹ Seattle Children's Research Institute, Center for Integrative Brain Research, Seattle, WA, USA.
¹⁰ Department of Pediatrics, Genetics Division, University of Washington, Seattle, WA, USA.
¹¹ Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, Institut de Biologie Paris Seine, France, 75005, Paris, France.
¹² Centre National de la Recherche Scientifique, CNRS, UMR8246, INSERM U1130, Neuroscience Paris Seine, France, 75005, Paris, France.
¹³ Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY, 10065, USA.
¹⁴ Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.
¹⁵ Developmental Biology Program, Sloan Kettering Institute, New York, NY, 10065, USA.
¹⁶ Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
¹⁷ Department of Integrative Physiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
¹⁸ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
¹⁹ Department Human Anatomy, IMIB-Arrixaca, University of Murcia, Murcia, Spain.
²⁰ Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
²¹ Anatomie und Zellbiologie, Anatomisches Institut, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
²² Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
²³ Institut de la Vision, UPMC Université de Paris 06, Paris, 75012, France.
²⁴ Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.
²⁵ MRC Centre for Developmental Neurobiology, King's College London, London, UK.
²⁶ Department of Cell Biology & Anatomy and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, T2N 4NI, AB, Canada.

PMID: 26439486
PMCID: PMC4846577
DOI: 10.1007/s12311-015-0724-2

Free PMC article

Review

Consensus Paper: Cerebellar Development

Ketty Leto et al. Cerebellum. 2016 Dec.

Free PMC article

. 2016 Dec;15(6):789-828.

doi: 10.1007/s12311-015-0724-2.

Authors

Affiliations

¹ Department of Neuroscience Rita Levi Montalcini, University of Turin, via Cherasco 15, 10026, Turin, Italy. ketty.leto@unito.it.
² Neuroscience Institute Cavalieri-Ottolenghi, University of Turin, Regione Gonzole 10, 10043, Orbassano, Torino, Italy. ketty.leto@unito.it.
³ Departments of Pathology & Immunology and Neuroscience, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX, 77030, USA.
⁴ Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
⁵ Department of Neuroscience Rita Levi Montalcini, University of Turin, via Cherasco 15, 10026, Turin, Italy.
⁶ Neuroscience Institute Cavalieri-Ottolenghi, University of Turin, Regione Gonzole 10, 10043, Orbassano, Torino, Italy.
⁷ Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4114 MRB III, Nashville, TN, 37232, USA.
⁸ Department of Microbiology and Physiological Systems and Program in Neuroscience, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605-2324, USA.
⁹ Seattle Children's Research Institute, Center for Integrative Brain Research, Seattle, WA, USA.
¹⁰ Department of Pediatrics, Genetics Division, University of Washington, Seattle, WA, USA.
¹¹ Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, Institut de Biologie Paris Seine, France, 75005, Paris, France.
¹² Centre National de la Recherche Scientifique, CNRS, UMR8246, INSERM U1130, Neuroscience Paris Seine, France, 75005, Paris, France.
¹³ Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY, 10065, USA.
¹⁴ Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.
¹⁵ Developmental Biology Program, Sloan Kettering Institute, New York, NY, 10065, USA.
¹⁶ Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
¹⁷ Department of Integrative Physiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
¹⁸ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
¹⁹ Department Human Anatomy, IMIB-Arrixaca, University of Murcia, Murcia, Spain.
²⁰ Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
²¹ Anatomie und Zellbiologie, Anatomisches Institut, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
²² Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
²³ Institut de la Vision, UPMC Université de Paris 06, Paris, 75012, France.
²⁴ Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.
²⁵ MRC Centre for Developmental Neurobiology, King's College London, London, UK.
²⁶ Department of Cell Biology & Anatomy and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, T2N 4NI, AB, Canada.

PMID: 26439486
PMCID: PMC4846577
DOI: 10.1007/s12311-015-0724-2

Abstract

The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.

Keywords: Cerebellum; Differentiation; Progenitors; Purkinje cells; Specification.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

1. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12138-43 - PubMed
1. J Comp Neurol. 2000 Jan 17;416(3):383-97 - PubMed
1. Brain Res. 2007 Apr 6;1140:19-25 - PubMed
1. Cell Death Differ. 2011 Jan;18(1):48-59 - PubMed
1. Nat Genet. 2004 Oct;36(10):1053-5 - PubMed

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Consensus Paper: Cerebellar Development

Affiliations

Consensus Paper: Cerebellar Development

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases