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. 2015 Oct 15:287:16-8.
doi: 10.1016/j.jneuroim.2015.07.013. Epub 2015 Jul 29.

Increased serum peroxiredoxin 5 levels in myasthenia gravis

Akiyuki Uzawa  1 , Naoki Kawaguchi  2 , Tetsuya Kanai  3 , Keiichi Himuro  3 , Fumiko Oda  3 , Satoshi Kuwabara  3
Affiliations

Increased serum peroxiredoxin 5 levels in myasthenia gravis

Akiyuki Uzawa et al. J Neuroimmunol. .

Abstract

Extracellular peroxiredoxin 5 (PRX5) is known to be an inflammatory mediator. The serum PRX5 levels of 40 patients with anti-acetylcholine receptor antibody-positive MG and those of 40 controls were measured. PRX5 levels in patients with MG were higher than those in the controls (P=0.045). Thymoma-associated MG patients showed higher PRX5 levels than late-onset MG patients and controls (P<0.05). There were significant associations between the serum PRX5 levels and high mobility group box 1 levels. PRX5 elevation in MG could be related to the neuromuscular junction breakdown and plays a pivotal role in the pathogenic inflammation of MG.

Keywords: Anti-acetylcholine receptor antibody; High mobility group box 1; Myasthenia gravis; Peroxiredoxin; Thymoma.

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