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. 1989 Feb 10;56(3):479-86.
doi: 10.1016/0092-8674(89)90250-x.

Constitutive mutants in the yeast pheromone response: ordered function of the gene products

D Blinder  1 , S Bouvier, D D Jenness
Affiliations

Constitutive mutants in the yeast pheromone response: ordered function of the gene products

D Blinder et al. Cell. .

Abstract

The alpha factor pheromone inhibits the division of yeast a cells. A general method was developed for isolating mutants that exhibit constitutive activation of the pheromone response pathway. A dominant allele of the STE4 locus was recovered in addition to recessive mutations in the SCG1 gene. SCG1 and STE4 are known to encode G alpha and G beta homologs, respectively. Analysis of double mutants suggests that the STE4 gene product functions after the SCG1 product but before the STE5 product.

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