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Comment
. 2015 Nov;36(11):665-667.
doi: 10.1016/j.it.2015.09.003. Epub 2015 Oct 1.

Beyond Genomics: Multidimensional Analysis of Cancer Therapy Resistance

Mary Philip  1 , Andrea Schietinger  2
Affiliations
Comment

Beyond Genomics: Multidimensional Analysis of Cancer Therapy Resistance

Mary Philip et al. Trends Immunol. 2015 Nov.

Abstract

Cancer resistance to therapy occurs through a selection process generally thought to be driven by mutations. In a recent study, Hugo et al. use multidimensional analysis of the dynamic genetic, transcriptional, epigenetic, and immune landscape alterations in baseline and MAPK inhibitor-resistant melanoma tumors, demonstrating a role for 'non-genomic' drivers in cancer evolution.

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Figures

Figure 1
Figure 1. Genomic and Non-Genomic Alterations in Cancer Evolution
Genetic, epigenetic, immune, and metabolic alterations coevolve during cancer development, therapy-induced cancer regression/remission, and pre-existing or acquired cancer therapy resistance/relapse. (Top left) Technologies that can be used for multidimensional data acquisition and analyses for cancer diagnostics. (Top right) Multimodal cancer therapies targeting one or multiple events of cancer evolution and progression.
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References

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    1. Paley MA, et al. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science. 2012;338:1220–1225. - PMC - PubMed

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