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Review
. 2015 Nov;136(5 Suppl):62S-71S.
doi: 10.1097/PRS.0000000000001773.

Aesthetic Uses of Neuromodulators: Current Uses and Future Directions

Michael S Gart  1 , Karol A Gutowski
Affiliations
Review

Aesthetic Uses of Neuromodulators: Current Uses and Future Directions

Michael S Gart et al. Plast Reconstr Surg. 2015 Nov.

Abstract

Background: The introduction of neuromodulators for aesthetic facial improvements greatly expanded the limits of nonsurgical facial rejuvenation. Although many current uses are considered "off-label," the widespread acceptance and favorable safety profile of properly used botulinum toxins have made them one of the most common aesthetic treatments available.

Methods: A literature review of current facial aesthetic uses of various botulinum toxin preparations was done, and general concepts were identified.

Results: Currently, Food and Drug Administration-approved botulinum toxin preparations onabotulinumtoxinA (Botox), abobotulinumtoxinA (Dysport), and incobotulinumtoxinA (Xeomin) have similar off-label indications and clinical uses.

Conclusions: Although not considered interchangeable, administration and clinical outcomes are not much different between the 3 commonly used botulinum products. The impact of botulinum products currently in development has yet to be determined.

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References

    1. Scott AB, Rosenbaum A, Collins CC. Pharmacologic weakening of extraocular muscles. Invest Ophthalmol. 1973;12:924–927
    1. Clark RP, Berris CE. Botulinum toxin: a treatment for facial asymmetry caused by facial nerve paralysis. Plast Reconstr Surg. 1989;84:353–355
    1. Carruthers JD, Carruthers JA. Treatment of glabellar frown lines with C. botulinum-A exotoxin. J Dermatol Surg Oncol. 1992;18:17–21
    1. Jandhyala R. Impact of botulinum toxin a on the quality of life of subjects following treatment of facial lines. J Clin Aesthet Dermatol. 2013;6:41–45
    1. Lewis MB, Bowler PJ. Botulinum toxin cosmetic therapy correlates with a more positive mood. J Cosmet Dermatol. 2009;8:24–26

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