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Comment
. 2015 Nov;12(11):610-1.
doi: 10.1038/nrgastro.2015.168. Epub 2015 Oct 6.

Regenerative medicine: Hepatic progenitor cells up their game in the therapeutic stakes

Malcolm R Alison  1 , Wey-Ran Lin  2
Affiliations
Comment

Regenerative medicine: Hepatic progenitor cells up their game in the therapeutic stakes

Malcolm R Alison et al. Nat Rev Gastroenterol Hepatol. 2015 Nov.

Abstract

Bipotential hepatic progenitor cells (HPCs) are recognized as making modest contributions to hepatocyte regeneration, though never credited with major liver repopulation. A new study in mice demonstrates HPCs can make a massive contribution to hepatocyte replacement, suggesting HPCs have the potential to be an effective cell therapy for liver failure.

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Comment on

  • Hepatic progenitor cells of biliary origin with liver repopulation capacity.
    Lu WY, Bird TG, Boulter L, Tsuchiya A, Cole AM, Hay T, Guest RV, Wojtacha D, Man TY, Mackinnon A, Ridgway RA, Kendall T, Williams MJ, Jamieson T, Raven A, Hay DC, Iredale JP, Clarke AR, Sansom OJ, Forbes SJ. Lu WY, et al. Nat Cell Biol. 2015 Aug;17(8):971-983. doi: 10.1038/ncb3203. Epub 2015 Jul 20. Nat Cell Biol. 2015. PMID: 26192438 Free PMC article.

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