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. 2015 Sep 16:9:323.
doi: 10.3389/fnins.2015.00323. eCollection 2015.

A FreeSurfer view of the cortical transcriptome generated from the Allen Human Brain Atlas

Leon French  1 , Tomáš Paus  2
Affiliations

A FreeSurfer view of the cortical transcriptome generated from the Allen Human Brain Atlas

Leon French et al. Front Neurosci. .
No abstract available

Keywords: FreeSurfer; atlas; cortex; gene expression; neuroanatomy; transcriptome.

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Figures

Figure 1
Figure 1
Characterization of correlations between individual donor profiles and the median profile. (A) Histogram of donor-to-median profile correlations. The dashed red line marks a correlation of 0.446, which corresponds to one sided p < 0.05 (derived from random simulations of donor expression profiles). Mean expression levels and overlaps with the “synaptic transmission” and “neuron part” gene ontology groups are provided for genes in four correlation ranges (marked as dotted vertical lines). Expression profiles for four representative genes that lie at the midpoints of each range are provided in (B) and marked in (A) with arrows (HTR1F, MRPS6, SOCS6, and NUP210L). The solid black line represents the median profile and the six donor profiles as dotted lines in (B). Each region is color-coded to indicate its cortical lobe: frontal (red), parietal (blue), temporal (purple) and occipital (green). Each symbol shape represents a specific donor.
Figure 2
Figure 2
Lateral (left) and medial (right) views of CNR1 gene expression data projected onto the FreeSurfer cortical regions in the left hemisphere of the fsaverage brain template. Expression (log2 intensity) ranges from 5 (blue), 5.92 (white), and red (6.83).
See this image and copyright information in PMC

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