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Review
. 2015 Sep 14:6:473.
doi: 10.3389/fimmu.2015.00473. eCollection 2015.

Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation

Kailin Lin  1 , Song Chen  2 , Gang Chen  2
Affiliations
Review

Role of Memory T Cells and Perspectives for Intervention in Organ Transplantation

Kailin Lin et al. Front Immunol. .

Abstract

Memory T cells are necessary for protective immunity against invading pathogens, especially under conditions of immunosuppression. However, their presence also threatens transplant survival, making transplantation a great challenge. Significant progress has been achieved in recent years in advancing our understanding of the role that memory T cells play in transplantation. This review focuses on the latest advances in our understanding of the involvement of memory T cells in graft rejection and transplant tolerance and discusses potential strategies for targeting memory T cells in order to minimize allograft rejection and optimize clinical outcomes.

Keywords: allograft rejection; memory T cells; therapy; tolerance; transplantation.

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