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Review
. 2015 Sep 22:5:207.
doi: 10.3389/fonc.2015.00207. eCollection 2015.

Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer

Annkathrin Hanssen  1 , Sonja Loges  2 , Klaus Pantel  1 , Harriet Wikman  1
Affiliations
Review

Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer

Annkathrin Hanssen et al. Front Oncol. .

Abstract

Lung cancer is the most common cause of cancer-related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we present and discuss epithelial cell adhesion molecule-dependent and -independent capture of CTCs in non-small cell lung cancer (NSCLC) and the clinical relevance of CTC detection and characterization. Taking blood samples and analyzing CTCs as "liquid biopsy" might be a far less invasive diagnostic strategy than biopsies of lung tumors or metastases. Moreover, sequential blood sampling allows to study the dynamic changes of tumor cells during therapy, in particular the development of resistant tumor cell clones.

Keywords: EpCAM; circulating tumor cells; liquid biopsy; non-small cell lung cancer.

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References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin (2015) 65:87–108.10.3322/caac.21262 - DOI - PubMed
    1. Camidge DR, Pao W, Sequist LV. Acquired resistance to TKIs in solid tumours: learning from lung cancer. Nat Rev Clin Oncol (2014) 11:473–81.10.1038/nrclinonc.2014.104 - DOI - PubMed
    1. Alix-Panabieres C, Pantel K. Challenges in circulating tumour cell research. Nat Rev Cancer (2014) 14:623–31.10.1038/nrc3820 - DOI - PubMed
    1. Krebs MG, Metcalf RL, Carter L, Brady G, Blackhall FH, Dive C. Molecular analysis of circulating tumour cells-biology and biomarkers. Nat Rev Clin Oncol (2014) 11:129–44.10.1038/nrclinonc.2013.253 - DOI - PubMed
    1. Alix-Panabieres C, Pantel K. Circulating tumor cells: liquid biopsy of cancer. Clin Chem (2013) 59:110–8.10.1373/clinchem.2012.194258 - DOI - PubMed

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