Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Sep 24:5:66.
doi: 10.3389/fcimb.2015.00066. eCollection 2015.

Commentary: The unliganded glucocorticoid receptor positively regulates the tumor suppressor gene BRCA1 through GABP beta

Hanan Polansky  1 , Adrian Javaherian  1
Affiliations
Comment

Commentary: The unliganded glucocorticoid receptor positively regulates the tumor suppressor gene BRCA1 through GABP beta

Hanan Polansky et al. Front Cell Infect Microbiol. .
No abstract available

Keywords: cancer; latent virus; microcompetition; stress; transcription factor.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Two pathways initiated by a stress signal lead to breast cancer. One pathway involves an increase in latent viral copy number (A). Another pathway involves an increase in cortisol∙GR binding (B). Both events lead to a decrease in GABPβ binding to the BRCA1 promoter, decrease in BRCA1 expression, and breast cancer.
See this image and copyright information in PMC

Comment on

References

    1. Adam G. I., Miller S. J., Ullerås E., Franklin G. C. (1996). Cell-type-specific modulation of PDGF-b regulatory elements via viral enhancer competition: a caveat for the use of reference plasmids in transient transfection assays. Gene 178, 25–29. 10.1016/0378-1119(96)00318-6 - DOI - PubMed
    1. Damin A. P., Karam R., Zettler C. G., Caleffi M., Alexandre C. O. (2004). Evidence for an association of human papillomavirus and breast carcinomas. Breast Cancer Res. Treat. 84, 131–137. 10.1023/B:BREA.0000018411.89667.0d - DOI - PubMed
    1. El-Shinawi M., Mohamed H. T., El-Ghonaimy E. A., Tantawy M., Younis A., Schneider R. J., et al. . (2013). Human cytomegalovirus infection enhances NF-kB/p65 signaling in inflammatory breast cancer patients. PLoS ONE 8:e55755. 10.1371/journal.pone.0055755 - DOI - PMC - PubMed
    1. Liu B. H., Wang X., Ma Y. X., Wang S. (2004). CMV enhancer/human PDGF-Beta promoter for neuron-specific transgene expression. Gene Ther. 11, 52–60. 10.1038/sj.gt.3302126 - DOI - PubMed
    1. Mazouni C., Fina F., Romain S., Ouafik L., Bonnier P., Brandone J.-M., et al. . (2011). Epstein-Barr virus as a marker of biological aggressiveness in breast cancer. Br. J. Cancer 104, 332–337. 10.1038/sj.bjc.6606048 - DOI - PMC - PubMed

MeSH terms

Substances