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. 2015 Oct 7;10(10):e0139206.
doi: 10.1371/journal.pone.0139206. eCollection 2015.

Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue

Barbara Lisowska  1 , Aleksander Lisowski  2 , Katarzyna Siewruk  3
Affiliations

Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue

Barbara Lisowska et al. PLoS One. .

Abstract

Objective: Evidence suggests that substance P (SP) is involved in chronic joint inflammation, such as the pathogenesis of rheumatoid arthritis and osteoarthritis. The goal of the research was to evaluate the correlation between chronic pain and changes in the SP level in patients with chronic inflammation of the connective tissue.

Methods: Patients with osteoarthritis and rheumatoid arthritis were enrolled in this study. The relationship between chronic pain intensity and the serum SP concentration was evaluated in these groups of patients with osteoarthritis and rheumatoid arthritis.

Results: The results showed a positive correlation between the serum SP concentrations and chronic pain intensity.

Conclusions: 1. The SP serum concentration was significantly different between the groups of patients with OA and RA. 2. There was a positive correlation between the serum SP concentration and chronic pain intensity in OA and RA patients.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The relationship between NPS and the serum concentration of substance P (SP) for OA patients.
Fig 2
Fig 2. Interaction between the serum concentration of substance P (SP) and the disease activity (DAS) and intensity of pain (NPS) for patients with RA.
See this image and copyright information in PMC

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