Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Oct 7;10(10):e0139748.
doi: 10.1371/journal.pone.0139748. eCollection 2015.

A Nation-Wide Cancer Registry-Based Study of Adenosquamous Carcinoma in Taiwan

Yuan-Tzu Lan  1 , Kuo-Hung Huang  2 , Chien-An Liu  3 , Ling-Chen Tai  4 , Ming-Huang Chen  5 , Yee Chao  5 , Anna Fen-Yau Li  6 , Shih-Hwa Chiou  7 , Yi-Ming Shyr  8 , Chew-Wun Wu  8 , Wen-Liang Fang  8
Affiliations

A Nation-Wide Cancer Registry-Based Study of Adenosquamous Carcinoma in Taiwan

Yuan-Tzu Lan et al. PLoS One. .

Abstract

Background: Adenosquamous carcinoma (ASC) is a rare disease involving various organs, yet there are no large-scale population-based comparative studies on ASC among different organs.

Methods: The incidence and overall survival of ASC among various organs in cases diagnosed in Taiwan from January 1, 2003 to December 31, 2010 were calculated and compared using data from the Taiwan Cancer Registry (TCR). The various organs were classified and divided into three different systems: the female reproductive, respiratory, and alimentary systems. Survival analysis were also compared among 30,850 patients diagnosed as ASC, adenocarcinoma (AC) or squamous cell carcinoma (SCC) in organs with frequent ASC.

Results: During the study period, a total of 576 ASC cases were diagnosed in Taiwan. The most common primary system was respiratory (73.8%), followed by alimentary (16.2%) and female reproductive (10%). The overall survival were significantly higher for cases involving the female reproductive system, followed by the respiratory and alimentary systems (P = 0.016). The median overall survival were worse in males than females for cases involving the respiratory system (22.4 vs. 31.8 months, P = 0.044). Multivariate analysis showed that age ≧ 65, more advanced T and N categories were independent unfavorable prognostic factors of overall survival in ASC. ASC histology is an independent unfavorable prognostic factor compared with AC and SCC.

Conclusions: ASC at an old age and more advanced T and N categories were found to be associated with a poor prognosis.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The age-standardized incidence rates of ASC according to different systems.
Fig 2
Fig 2. The overall survival were significantly higher in ASC patients with tumor located in the female reproductive system, followed by the respiratory system and alimentary system (P = 0.016).
Fig 3
Fig 3. The annual incidence rates of AC, SCC and ASC in different organs.
See this image and copyright information in PMC

References

    1. Bosman FT, Carneiro F, Hruban RH, Theise ND. (2010) WHO classification of tumours of the digestive system 4th ed. IARC.
    1. Cha YJ, Kim GJ, Park BW, Koo JS. (2014) Low-grade adenosquamous carcinoma of the breast with diverse expression patterns of myoepithelial cell markers on immunohistochemistry: a case study. Korean J Pathol 48:229–33. 10.4132/KoreanJPathol.2014.48.3.229 - DOI - PMC - PubMed
    1. Eifel PJ, Burke TW, Morris M, Smith TL. (1995) Adenocarcinoma as an independent risk factor for disease recurrence in patients with stage IB cervical carcinoma. Gynecol Oncol 59: 38–44. - PubMed
    1. Nakanishi T, Ishikawa H, Suzuki Y, Inoue T, Nakamura S, Kuzuya K. (2000) A comparison of prognoses of pathologic stage Ib adenocarcinoma and squamous cell carcinoma of the uterine cervix. Gynecol Oncol 79: 289–293. - PubMed
    1. Huang YT, Wang CC, Tsai CS, Lai CH, Chang TC, Chou HH. (2012) Clinical behaviors and outcomes for adenocarcinoma or adenosquamous carcinoma of cervix treated by radical hysterectomy and adjuvant radiotherapy or chemoradiotherapy. Int J Radiat Oncol Biol Phys 84: 420–427. 10.1016/j.ijrobp.2011.12.013 - DOI - PubMed

Publication types