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Comment
. 2015 Oct 6;22(4):538-9.
doi: 10.1016/j.cmet.2015.09.018.

Making Biological Sense of GWAS Data: Lessons from the FTO Locus

Mark A Herman  1 , Evan D Rosen  2
Affiliations
Free article
Comment

Making Biological Sense of GWAS Data: Lessons from the FTO Locus

Mark A Herman et al. Cell Metab. .
Free article

Abstract

GWAS have yielded many candidate loci for complex diseases like obesity, but interpreting the biological context of these findings has been difficult. Claussnitzer et al. (2015) use a sophisticated combination of bioinformatic and experimental approaches to address this bottleneck for variants in the FTO locus that associate with obesity.

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  • FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
    Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M. Claussnitzer M, et al. N Engl J Med. 2015 Sep 3;373(10):895-907. doi: 10.1056/NEJMoa1502214. Epub 2015 Aug 19. N Engl J Med. 2015. PMID: 26287746 Free PMC article.

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