Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory

Kelvin S Ng¹, Thomas M Kuncewicz¹, Jeffrey M Karp²

Affiliations

¹ Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA; Department of Medicine, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
² Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA; Department of Medicine, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: bwhkarp@gmail.com.

PMID: 26445510
DOI: 10.1016/j.cmet.2015.09.019

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Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory

Kelvin S Ng et al. Cell Metab. 2015.

Free article

. 2015 Oct 6;22(4):541-3.

doi: 10.1016/j.cmet.2015.09.019.

Authors

Kelvin S Ng¹, Thomas M Kuncewicz¹, Jeffrey M Karp²

Affiliations

¹ Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA; Department of Medicine, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
² Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA; Department of Medicine, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: bwhkarp@gmail.com.

PMID: 26445510
DOI: 10.1016/j.cmet.2015.09.019

Abstract

While mesenchymal stem cells (MSCs) are rapidly cleared from the body following systemic transplantation, their therapeutic benefits typically persist. In this issue, Liu et al. (2015) reveal that the ability of transplanted MSCs to alleviate osteoporosis in systemic lupus erythematosus is maintained through epigenetic changes conferred by secretory action of the MSCs.

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MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.
Liu S, Liu D, Chen C, Hamamura K, Moshaverinia A, Yang R, Liu Y, Jin Y, Shi S. Liu S, et al. Cell Metab. 2015 Oct 6;22(4):606-18. doi: 10.1016/j.cmet.2015.08.018. Epub 2015 Sep 10. Cell Metab. 2015. PMID: 26365178 Free PMC article.

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Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory

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Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory

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