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Comparative Study
. 2015 Oct 7:14:104.
doi: 10.1186/s12937-015-0089-x.

A pilot comparison of phospolipidated lutein to conventional lutein for effects on plasma lutein concentrations in adult people

Robert A DiSilvestro  1 , Sara Thomas  2 , Earl Harrison  2 , Alice Epitropoulos  3
Affiliations
Comparative Study

A pilot comparison of phospolipidated lutein to conventional lutein for effects on plasma lutein concentrations in adult people

Robert A DiSilvestro et al. Nutr J. .

Abstract

Background: The percent absorption of lutein from supplements falls well below that from lutein enriched egg yolk, a rich source of phospholipids. Therefore, a supplement of lutein plus phospholipids was tested for effects on serum accumulation.

Methods: A 10 day supplementation with a solid-lipid particle (SLP) lutein complex or conventional lutein ester was done in apparently healthy people (both supplement types taken with fat containing meals). Plasma lutein was measured pre- and post-supplementation as well as 7 days after supplementation stopped. Changes within each supplement group were analyzed by paired t-test; group comparisons were done by unpaired t-test.

Results: The solid-lipid particle complex lutein gave much higher plasma lutein values than conventional lutein ester. The lutein complex showed superior effects based on absolute mean value after 10 days of supplementation, change in value from baseline to 10 days, and value at 7 days after supplement discontinuation.

Conclusions: A solid lipid lutein complex strongly increased plasma lutein levels compared to a conventional form.

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Figures

Fig. 1
Fig. 1
Plasma lutein concentrations before and after 10 days supplementation with 10 mg/day of lutein. Lutein 1 = lutein ester. Lutein 2 = solid-lipid particle complex lutein. *Significantly different from pre value, p < 0.001, paired t-test
Fig. 2
Fig. 2
The change in plasma lutein concentrations after 10 days of supplementation with 10 mg/day of lutein. Lutein 1 = lutein ester. Lutein 2 = solid-lipid particle complex lutein. *Significantly different from pre value, p < 0.002, unpaired t-test
Fig. 3
Fig. 3
Plasma lutein concentrations 7 days post-supplementation (10 mg/day of lutein for 10 days). Lutein 1 = lutein ester. Lutein 2 = solid-lipid particle complex lutein. *Significantly different from Lutein1 value, p < 0.001, unpaired t-test
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