Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Feb;86(3):797-801.
doi: 10.1073/pnas.86.3.797.

DNA binding specificity of the Arc and Mnt repressors is determined by a short region of N-terminal residues

K L Knight  1 , R T Sauer
Affiliations

DNA binding specificity of the Arc and Mnt repressors is determined by a short region of N-terminal residues

K L Knight et al. Proc Natl Acad Sci U S A. 1989 Feb.

Abstract

The Arc and Mnt repressors of phage P22 are related proteins that bind to different operator DNA sites. By creating a hybrid Arc-Mnt protein, we show that the binding specificity of Mnt can be switched to that of Arc by replacing six residues at the N terminus of Mnt with the corresponding nine residues from Arc.

PubMed Disclaimer

References

    1. J Mol Biol. 1987 May 20;195(2):323-31 - PubMed
    1. Proteins. 1986 Dec;1(4):302-11 - PubMed
    1. Biochemistry. 1988 Mar 22;27(6):2088-94 - PubMed
    1. J Mol Biol. 1975 Feb 5;91(4):439-62 - PubMed
    1. Nucleic Acids Res. 1981 Jul 10;9(13):3047-60 - PubMed

Publication types

LinkOut - more resources