Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Nov;15(11):683-91.
doi: 10.1038/nri3904. Epub 2015 Oct 9.

γδ T cells in cancer

Affiliations
Review

γδ T cells in cancer

Bruno Silva-Santos et al. Nat Rev Immunol. 2015 Nov.

Abstract

With the promise of T cell-based therapy for cancer finally becoming reality, this Review focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells have well-established protective roles in cancer, largely on the basis of their potent cytotoxicity and interferon-γ production. Besides this, recent studies have revealed a series of tumour-promoting functions that are linked to interleukin-17-producing γδ T cells. Here, we integrate the current knowledge from both human and mouse studies to highlight the potential of γδ T cell modulation to improve cancer immunotherapy.

PubMed Disclaimer

References

    1. Blood. 2009 Jul 9;114(2):310-7 - PubMed
    1. Nat Med. 2015 Aug;21(8):938-45 - PubMed
    1. J Exp Med. 2003 Aug 4;198(3):433-42 - PubMed
    1. Nat Immunol. 2008 Feb;9(2):146-54 - PubMed
    1. J Exp Med. 2004 Mar 15;199(6):879-84 - PubMed

Publication types

Substances

LinkOut - more resources