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Editorial
. 2015 Oct 13;6(31):30441-2.
doi: 10.18632/oncotarget.5962.

Cutaneous bacteria induce immunosuppression

Yuliya Skabytska, Tilo Biedermann  1
Affiliations
Editorial

Cutaneous bacteria induce immunosuppression

Yuliya Skabytska et al. Oncotarget. .
No abstract available

Keywords: IL-6; atopic dermatitis; cutaneous bacteria; myeloidderived suppressor cells; skin inflammation.

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Figures

Figure 1
Figure 1. Cutaneous Staphylococcus aureus induce systemic immune suppression
Cutaneous exposure to TLR2/TLR6 but not TLR2/TLR1 ligands induces systemic immune suppression following cutaneous bacterial colonization. This is due to a release of IL-6 by keratinocytes, which causes a systemic induction of Gr1+CD11b+ myeloid-derived suppressor cells (MDSCs) directly suppressing inflammation.
See this image and copyright information in PMC

References

    1. Biedermann T. Acta Derm Venereol. 2006;86:99–109. - PubMed
    1. Travers JB, et al. J Allergy Clin Immunol. 2010;125:146–152. e141-142. - PMC - PubMed
    1. Volz T, et al. Exp Dermatol. 2011;21:61–69. - PubMed
    1. Kaesler S, et al. J Allergy Clin Immunol. 2014;134:92–99. - PubMed
    1. Skabytska Y, et al. Immunity. 2014;41:762–775. - PubMed

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