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Comment
. 2015 Oct 8;163(2):273-4.
doi: 10.1016/j.cell.2015.09.040.

"A Sledgehammer Breaks Glass but Forges Steel": Bacteria Adhesion Shapes Gut Immunity

Virginia A Pedicord  1 , Daniel Mucida  2
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Free article
Comment

"A Sledgehammer Breaks Glass but Forges Steel": Bacteria Adhesion Shapes Gut Immunity

Virginia A Pedicord et al. Cell. .
Free article

Abstract

Gut bacteria are known to affect immune cell development, but most intestinal lymphocytes have no direct contact with luminal bacteria. Two studies by Atarashi et al. and Sano et al. shed light on how bacterial adhesion can cue intestinal epithelial cells to direct differentiation of gut T cells.

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  • Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.
    Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, Suda W, Imaoka A, Setoyama H, Nagamori T, Ishikawa E, Shima T, Hara T, Kado S, Jinnohara T, Ohno H, Kondo T, Toyooka K, Watanabe E, Yokoyama S, Tokoro S, Mori H, Noguchi Y, Morita H, Ivanov II, Sugiyama T, Nuñez G, Camp JG, Hattori M, Umesaki Y, Honda K. Atarashi K, et al. Cell. 2015 Oct 8;163(2):367-80. doi: 10.1016/j.cell.2015.08.058. Epub 2015 Sep 24. Cell. 2015. PMID: 26411289 Free PMC article.
  • An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses.
    Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR. Sano T, et al. Cell. 2015 Oct 8;163(2):381-93. doi: 10.1016/j.cell.2015.08.061. Epub 2015 Sep 24. Cell. 2015. PMID: 26411290 Free PMC article.

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