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Meta-Analysis
. 2015 Oct 9:21:3048-53.
doi: 10.12659/MSM.894625.

Association Between TP53 Gene Codon 72 Polymorphism and Acute Myeloid Leukemia Susceptibility: Evidence Based on a Meta-Analysis

Xiao-Lan Ruan  1 , Sheng Li  2 , Peiliang Geng  3 , Xian-Tao Zeng  2 , Guo-Zheng Yu  2 , Xiang-Yu Meng  2 , Qing-Ping Gao  1 , Xu-Bin Ao  1
Affiliations
Meta-Analysis

Association Between TP53 Gene Codon 72 Polymorphism and Acute Myeloid Leukemia Susceptibility: Evidence Based on a Meta-Analysis

Xiao-Lan Ruan et al. Med Sci Monit. .

Abstract

Background: Many studies have reported that the p53 codon 72 polymorphism is associated with acute myeloid leukemia (AML) susceptibility; however, the conclusions are inconsistent. Therefore, we performed this meta-analysis to obtain a more precise result.

Material and methods: We searched PubMed to identify relevant studies, and 6 published case-control studies were retrieved, including 924 AML patients and 3832 controls. Odds ratio (OR) with corresponding 95% confidence interval (95%CI) was applied to assess the association between p53 codon 72 polymorphism and AML susceptibility. The meta-analysis was performed with Comprehensive Meta-Analysis software, version 2.2.

Results: Overall, no significant association between p53 codon 72 polymorphism and AML susceptibility was found in this meta-analysis (Pro vs. Arg: OR=0.94, 95%CI=0.81-1.10; Pro/Pro vs. Arg/Arg: OR=0.93, 95%CI=0.71-1.22; Arg/Pro vs. Arg/Arg: OR=0.79, 95%CI=0.55-1.13; (Pro/Pro + Arg/Pro) vs. Arg/Arg: OR=0.84, 95%CI=0.62-1.13; Pro/Pro vs. (Arg/Arg + Arg/Pro): OR=1.06, 95%CI=0.83-1.35). Similar results were also found in stratified analysis according to ethnicity and source of controls.

Conclusions: Our meta-analysis demonstrates that p53 codon 72 polymorphism may not be a risk factor for AML, which should be verified in future studies.

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Figures

Figure 1
Figure 1
Flowchart of study selection.
Figure 2
Figure 2
Overall ORs for AML susceptibility and p53 genetic polymorphism under Pro/Pro vs. Arg/Arg model with random-effects model.
Figure 3
Figure 3
Forest plot of sensitivity analysis (Pro/Pro vs. Arg/Arg model).
Figure 4
Figure 4
Funnel plot for publication bias (Pro/Pro vs. Arg/Arg mode).
See this image and copyright information in PMC

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