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Comment
. 2015 Oct 9:4:e11409.
doi: 10.7554/eLife.11409.

Mapping neural circuits with CLARITY

Amanda M Willard  1 , Aryn H Gittis  1
Affiliations
Comment

Mapping neural circuits with CLARITY

Amanda M Willard et al. Elife. .

Abstract

The use of whole-brain imaging has shed new light on the organization of the dopamine system.

Keywords: anatomy; dopamine; input; monosynaptic; mouse; neuroscience; rabies virus; striatum.

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Conflict of interest statement

Competing interests:The authors declare that no competing interests exist.

Figures

Figure 1.
Figure 1.. Inputs and outputs of dopamine neurons.
Dopamine (DA) neurons are found in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNc). Dopamine neurons projecting to the tail of the striatum (TS) receive the majority of their input from the globus pallidus (GP), the subthalamic nucleus (STN), and the zona incerta (ZI), with a small amount of input coming from the ventral striatum (VS). Dopamine neurons that project to the cortex, amygdala (Amy), globus pallidus, ventral striatum and dorsal striatum (DS) receive the majority of their inputs from the following regions: the ventral striatum, dorsal striatum, ventral pallidum (VP), lateral hypothalamus (LHy), and preoptic area (POA). In Parkinson’s disease, dopamine neurons projecting to the posterior putamen (which is functionally similar to the tail of the striatum) are the first to degenerate (Kish et al., 1988), so their unique pattern of inputs is especially interesting to researchers.
See this image and copyright information in PMC

Comment on

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