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Review
. 2015 Nov 27;290(48):28623-30.
doi: 10.1074/jbc.R115.657130. Epub 2015 Oct 9.

The Regulation of Synaptic Protein Turnover

Beatriz Alvarez-Castelao  1 , Erin M Schuman  2
Affiliations
Review

The Regulation of Synaptic Protein Turnover

Beatriz Alvarez-Castelao et al. J Biol Chem. .

Abstract

Emerging evidence indicates that protein synthesis and degradation are necessary for the remodeling of synapses. These two processes govern cellular protein turnover, are tightly regulated, and are modulated by neuronal activity in time and space. The anisotropic anatomy of the neurons presents a challenge for the study of protein turnover, but the understanding of protein turnover in neurons and its modulation in response to activity can help us to unravel the fine-tuned changes that occur at synapses in response to activity. Here we review the key experimental evidence demonstrating the role of protein synthesis and degradation in synaptic plasticity, as well as the turnover rates of specific neuronal proteins.

Keywords: neuron; protein degradation; protein synthesis; protein turnover; synapse; synaptic plasticity.

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References

    1. Peters A., and Palay S. L. (1996) The morphology of synapses. J. Neurocytol. 25, 687–700 - PubMed
    1. Eagle H., Piez K. A., Fleischman R., and Oyama V. I. (1959) Protein turnover in mammalian cell cultures. J. Biol. Chem. 234, 592–597 - PubMed
    1. Jovanovic M., Rooney M. S., Mertins P., Przybylski D., Chevrier N., Satija R., Rodriguez E. H., Fields A. P., Schwartz S., Raychowdhury R., Mumbach M. R., Eisenhaure T., Rabani M., Gennert D., Lu D., Delorey T., Weissman J. S., Carr S. A., Hacohen N., and Regev A. (2015) Dynamic profiling of the protein life cycle in response to pathogens. Science 347, 1259038. - PMC - PubMed
    1. Fierro-Monti I., Racle J., Hernandez C., Waridel P., Hatzimanikatis V., and Quadroni M. (2013) A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitor. PLoS ONE 8, e80423. - PMC - PubMed
    1. Rizzoli S. O. (2014) Synaptic vesicle recycling: steps and principles. EMBO J. 33, 788–822 - PMC - PubMed

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