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Review
. 2015 Nov:80:131-142.
doi: 10.1016/j.bone.2015.03.015.

Inflammation induced loss of skeletal muscle

Priya Londhe  1 , Denis C Guttridge  2
Affiliations
Review

Inflammation induced loss of skeletal muscle

Priya Londhe et al. Bone. 2015 Nov.

Abstract

Inflammation is an important contributor to the pathology of diseases implicated in skeletal muscle dysfunction. A number of diseases and disorders including inflammatory myopathies and Chronic Obstructive Pulmonary Disorder (COPD) are characterized by chronic inflammation or elevation of the inflammatory mediators. While these disease states exhibit different pathologies, all have in common the loss of skeletal muscle mass and a deregulated skeletal muscle physiology. Pro-inflammatory cytokines are key contributors to chronic inflammation found in many of these diseases. This section of the review focuses on some of the known inflammatory disorders like COPD, Rheumatoid Arthritis (RA) and inflammatory myopathies that display skeletal muscle atrophy and also provides the reader an overview of the mediators of inflammation, their signaling pathways, and mechanisms of action. This article is part of a Special Issue entitled "Muscle Bone Interactions".

Keywords: Atrophy; Cytokines; Differentiation; Inflammation; Muscle; Skeletal.

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Figures

Figure 1
Figure 1. The drivers of muscle wasting in chronic inflammatory diseases
The figure depicts the inflammatory cytokines that contribute to muscle wasting. The degree of involvement of a particular cytokine is denoted by the width of individual arrows. Due to elevated expression of cytokines in these diseases, the balance is tipped towards hypercatabolism resulting in loss of muscle mass
See this image and copyright information in PMC

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