Comparative Study
doi: 10.1038/337615a0.
Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
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- PMID: 2645523
- DOI: 10.1038/337615a0
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Comparative Study
Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
Nature.
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Abstract
The crystal structure of the protease of the human immunodeficiency virus type (HIV-1), which releases structural proteins and enzymes from viral polyprotein products, has been determined to 3 A resolution. Large regions of the protease dimer, including the active site, have structural homology to the family of microbial aspartyl proteases. The structure suggests a mechanism for the autoproteolytic release of protease and a role in the control of virus maturation.
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