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Meta-Analysis
. 2015 Oct 12:5:14951.
doi: 10.1038/srep14951.

Diagnostic Value of Vestibular Evoked Myogenic Potentials in Endolymphatic Hydrops: A Meta-Analysis

Sulin Zhang  1   2 , Yangming Leng  1   2 , Bo Liu  1   2 , Hao Shi  3 , Meixia Lu  3 , Weijia Kong  1   2   4
Affiliations
Meta-Analysis

Diagnostic Value of Vestibular Evoked Myogenic Potentials in Endolymphatic Hydrops: A Meta-Analysis

Sulin Zhang et al. Sci Rep. .

Abstract

In this study, we evaluated the clinical diagnostic value of vestibular evoked myogenic potentials (VEMPs) for endolymphatic hydrops (EH) by systematic review and Meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under summary receiver operating characteristic curves (AUC) were calculated. Subgroup analysis and publication bias assessment were also conducted. The pooled sensitivity and the specificity were 49% (95% CI: 46% to 51%) and 95% (95% CI: 94% to 96%), respectively. The pooled positive likelihood ratio was 18.01 (95% CI: 9.45 to 34.29) and the pooled negative likelihood ratio was 0.54 (95% CI: 0.47 to 0.61). AUC was 0.78 and the pooled diagnostic odds ratio of VEMPs was 39.89 (95% CI: 20.13 to 79.03). In conclusion, our present meta-analysis has demonstrated that VEMPs test alone is not sufficient for Meniere's disease or delayed endolymphatic hydrops diagnosis, but that it might be an important component of a test battery for diagnosing Meniere's disease or delayed endolymphatic hydrops. Moreover, VEMPs, due to its high specificity and non-invasive nature, might be used as a screening tool for EH.

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Figures

Figure 1
Figure 1. Flowchart for the selection procedure for eligible studies.
Figure 2
Figure 2. Evaluation of the methodological quality of the included studies according to quality assessment diagnostic accuracy studies tool (QUADAS) criteri.
Figure 3
Figure 3. Forest plot of the sensitivity of included studies, summary sensitivity and I2 statistic for heterogeneity.
Figure 4
Figure 4. Forest plot of the specificity of included studies, summary specificity and I2 statistic for heterogeneity.
Figure 5
Figure 5. Hierarchical summary receiver operating characteristic curves of VEMPs for detecting EH.
The red square represents the summary estimate sensitivity and specificity with 95% confidence region and 95% prediction region for the diagnosis value of EH by VEMPs. The size of the circles indicates the total number in each study.
Figure 6
Figure 6. Publication bias was evaluated by Deek’s funnel plots.
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