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Review
. 2016 Mar;1859(3):455-61.
doi: 10.1016/j.bbagrm.2015.10.004. Epub 2015 Oct 8.

Linker histone H1 and protein-protein interactions

Anna A Kalashnikova  1 , Ryan A Rogge  1 , Jeffrey C Hansen  2
Affiliations
Review

Linker histone H1 and protein-protein interactions

Anna A Kalashnikova et al. Biochim Biophys Acta. 2016 Mar.

Abstract

Linker histones H1 are ubiquitous chromatin proteins that play important roles in chromatin compaction, transcription regulation, nucleosome spacing and chromosome spacing. H1 function in DNA and chromatin structure stabilization is well studied and established. The current paradigm of linker histone mode of function considers all other cellular roles of linker histones to be a consequence from H1 chromatin compaction and repression. Here we review the multiple processes regulated by linker histones and the emerging importance of protein interactions in H1 functioning. We propose a new paradigm which explains the multi functionality of linker histones through linker histones protein interactions as a way to directly regulate recruitment of proteins to chromatin.

Keywords: Chromatin; Genome; Intrinsic disorder; Nucleolus; Nucleosome; Transcription; mRNA splicing.

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Conflict of interest statement

Statement of Conflicts of Interests

The authors declare no conflicts of interests.

Figures

Figure 1
Figure 1
Distribution of calculated pIs for nuclear H1-binding proteins.
Figure 2
Figure 2
A synopsis of H1-protein interactions in the nucleolus. Adapted from [59].
See this image and copyright information in PMC

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