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Comment
. 2016 Aug;174(3):483-5.
doi: 10.1111/bjh.13781. Epub 2015 Oct 12.

Chronic inflammatory autoimmune disorders are a risk factor for red blood cell alloimmunization

Alex B Ryder  1 , Jeanne E Hendrickson  1   2 , Christopher A Tormey  3   4
Affiliations
Comment

Chronic inflammatory autoimmune disorders are a risk factor for red blood cell alloimmunization

Alex B Ryder et al. Br J Haematol. 2016 Aug.
No abstract available

Keywords: RBC alloantibodies; RBC alloimmunization; blood group antigens; chronic inflammatory disorders; inflammation.

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Conflict of interest statement

Conflicts of interest

The authors (ABR, JEH, CAT) report no relevant financial conflicts of interest.

Figures

Fig 1.
Fig 1.
(A) The number and specificity of alloantibodies detected among patients with autoimmune disease. Because some patients made >1 alloantibody, the total number of antibodies detected was 50 (1·4 antibodies/alloimmunized patient). Alloantibodies falling under the ‘Others’ category included: anti-c, - S, -P1, -Lea, -Kna, and -McCa (all n = 1). One unspecified alloantibody reactive at 37°C and anti-human globulin phase was also detected in this cohort (detected in the patient with anti-P1), but this alloantibody is not reflected in the figure above as the definitive specificity could not be identified during the retrospective review. Only 4·0% of alloantibodies (2/50; anti-Kna and -McCa) were considered uncommon and both of these antibodies were detected in the same patient. The determination of uncommon antibody specificities was made by comparing our results to those generated from large studies of general, hospital-based alloimmunized patients (Ramsey & Smietana, 1995; Tormey et al, 2008; Gehrie & Tormey, 2014). (B) The proportion of transfused patients with a chronic, autoimmune disease versus the proportion of alloimmunized patients with a chronic, autoimmune disease. Of randomly selected patients who underwent transfusion, 8·4% (21/250) had an underlying chronic autoimmune disorder. By comparison, 15·9% (35/220) of alloimmunized patients were noted to have an autoimmune disease. The ratio of alloimmunized patients with an autoimmune disease to those without (0·19) was significantly different than the ratio of transfused patients with an autoimmune disease to those without (0·09; P = 0 012; the asterisk (*) indicates a significant difference between the proportions of compared patients). pts = patients; w/o = without.
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Comment on

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