Diagnosis of Food Allergy

doi:10.1016/j.pcl.2015.07.009

Review

. 2015 Dec;62(6):1393-408.

doi: 10.1016/j.pcl.2015.07.009. Epub 2015 Sep 7.

Diagnosis of Food Allergy

Rebecca Sharon Chinthrajah¹, Dana Tupa², Benjamin T Prince³, Whitney Morgan Block⁴, Jaime Sou Rosa⁵, Anne Marie Singh⁶, Kari Nadeau⁵

Affiliations

¹ Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Sean N Parker Center for Allergy Research, Stanford University, Stanford University School of Medicine, 269 Campus Drive, CCSR 3215, MC 5366, Stanford, CA 94305-5101, USA. Electronic address: schinths@stanford.edu.
² Sean N Parker Center for Allergy Research, Stanford University, Stanford University School of Medicine, 1291 Welch Road, Grant Building S303, Stanford, CA 94305, USA.
³ Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine, 225 East Chicago Avenue Box 60, Chicago, IL, USA.
⁴ Sean N Parker Center for Allergy Research, Stanford University, 2500 Grant Road, PEC, 4th Floor Tower C, Mountain View, CA 94040, USA.
⁵ Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Sean N Parker Center for Allergy Research, Stanford University, Stanford University School of Medicine, 269 Campus Drive, CCSR 3215, MC 5366, Stanford, CA 94305-5101, USA.
⁶ Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 240 East Huron Street, M-317, McGaw Pavilion, Chicago, IL 60611, USA.

PMID: 26456439
PMCID: PMC5316471
DOI: 10.1016/j.pcl.2015.07.009

Review

Diagnosis of Food Allergy

Rebecca Sharon Chinthrajah et al. Pediatr Clin North Am. 2015 Dec.

. 2015 Dec;62(6):1393-408.

doi: 10.1016/j.pcl.2015.07.009. Epub 2015 Sep 7.

Authors

Rebecca Sharon Chinthrajah¹, Dana Tupa², Benjamin T Prince³, Whitney Morgan Block⁴, Jaime Sou Rosa⁵, Anne Marie Singh⁶, Kari Nadeau⁵

Affiliations

¹ Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Sean N Parker Center for Allergy Research, Stanford University, Stanford University School of Medicine, 269 Campus Drive, CCSR 3215, MC 5366, Stanford, CA 94305-5101, USA. Electronic address: schinths@stanford.edu.
² Sean N Parker Center for Allergy Research, Stanford University, Stanford University School of Medicine, 1291 Welch Road, Grant Building S303, Stanford, CA 94305, USA.
³ Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine, 225 East Chicago Avenue Box 60, Chicago, IL, USA.
⁴ Sean N Parker Center for Allergy Research, Stanford University, 2500 Grant Road, PEC, 4th Floor Tower C, Mountain View, CA 94040, USA.
⁵ Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Sean N Parker Center for Allergy Research, Stanford University, Stanford University School of Medicine, 269 Campus Drive, CCSR 3215, MC 5366, Stanford, CA 94305-5101, USA.
⁶ Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 240 East Huron Street, M-317, McGaw Pavilion, Chicago, IL 60611, USA.

PMID: 26456439
PMCID: PMC5316471
DOI: 10.1016/j.pcl.2015.07.009

Abstract

The prevalence of food allergies has been on the increase over the last 2 decades. Diagnosing food allergies can be complicated, as there are multiple types that have distinct clinical and immunologic features. Food allergies are broadly classified into immunoglobulin E (IgE)-mediated, non-IgE-mediated, or mixed food allergic reactions. This review focuses on the clinical manifestations of the different categories of food allergies and the different tests available to guide the clinician toward an accurate diagnosis.

Keywords: Component testing; Elimination diets; Food allergy; IgE-mediated; Non–IgE-mediated; Oral food challenge; Skin-prick testing.

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Conflict of interest statement

The authors have no relevant conflicts of interest to disclose.

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References

1. Jackson KD, Howie L, Akinbami LJ. Trends in allergic conditions among children: United States, 1997–2011. NCHS data brief. 2013;121:1–8. - PubMed
1. Sampson HA, Aceves S, Bock SA, et al. Food allergy: a practice parameter update-2014. J Allergy Clin Immunol. 2014;134(5):1016–1025. e1043. - PubMed
1. Sicherer SH, Wood RA. Advances in diagnosing peanut allergy. The Journal of Allergy and Clinical Immunology: In Practice. 2013;1(1):1–13. - PubMed
1. Commins SP, Satinover SM, Hosen J, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1, 3-galactose. Journal of Allergy and Clinical Immunology. 2009;123(2):426–433. e422. - PMC - PubMed
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[1] Jackson KD, Howie L, Akinbami LJ. Trends in allergic conditions among children: United States, 1997–2011. NCHS data brief. 2013;121:1–8. - PubMed

[2] Jackson KD, Howie L, Akinbami LJ. Trends in allergic conditions among children: United States, 1997–2011. NCHS data brief. 2013;121:1–8. - PubMed

[3] Sampson HA, Aceves S, Bock SA, et al. Food allergy: a practice parameter update-2014. J Allergy Clin Immunol. 2014;134(5):1016–1025. e1043. - PubMed

[4] Sampson HA, Aceves S, Bock SA, et al. Food allergy: a practice parameter update-2014. J Allergy Clin Immunol. 2014;134(5):1016–1025. e1043. - PubMed

[5] Sicherer SH, Wood RA. Advances in diagnosing peanut allergy. The Journal of Allergy and Clinical Immunology: In Practice. 2013;1(1):1–13. - PubMed

[6] Sicherer SH, Wood RA. Advances in diagnosing peanut allergy. The Journal of Allergy and Clinical Immunology: In Practice. 2013;1(1):1–13. - PubMed

[7] Commins SP, Satinover SM, Hosen J, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1, 3-galactose. Journal of Allergy and Clinical Immunology. 2009;123(2):426–433. e422. - PMC - PubMed

[8] Commins SP, Satinover SM, Hosen J, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1, 3-galactose. Journal of Allergy and Clinical Immunology. 2009;123(2):426–433. e422. - PMC - PubMed

[9] Biedermann T, Wölbing F. Anaphylaxis: opportunities of stratified medicine for diagnosis and risk assessment. Allergy. 2013;68(12) - PubMed

[10] Biedermann T, Wölbing F. Anaphylaxis: opportunities of stratified medicine for diagnosis and risk assessment. Allergy. 2013;68(12) - PubMed

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Diagnosis of Food Allergy

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Diagnosis of Food Allergy

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