Review

. 2015 Dec;62(6):1479-92.

doi: 10.1016/j.pcl.2015.07.007. Epub 2015 Sep 7.

Gut Microbiome and the Development of Food Allergy and Allergic Disease

Benjamin T Prince¹, Mark J Mandel², Kari Nadeau³, Anne Marie Singh⁴

Affiliations

¹ Division of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA; Division of Allergy and Immunology, Department of Medicine, Northwestern Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA.
² Department of Microbiology-Immunology, Northwestern Feinberg School of Medicine, Northwestern University, Searle Building 3-403, 320 E. Superior Street, Chicago, IL 60611, USA.
³ Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, 730 Welch Rd, Stanford, CA 94305, USA.
⁴ Division of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA; Division of Allergy and Immunology, Department of Medicine, Northwestern Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA. Electronic address: anne-singh@northwestern.edu.

PMID: 26456445
PMCID: PMC4721650
DOI: 10.1016/j.pcl.2015.07.007

Review

Gut Microbiome and the Development of Food Allergy and Allergic Disease

Benjamin T Prince et al. Pediatr Clin North Am. 2015 Dec.

. 2015 Dec;62(6):1479-92.

doi: 10.1016/j.pcl.2015.07.007. Epub 2015 Sep 7.

Authors

Benjamin T Prince¹, Mark J Mandel², Kari Nadeau³, Anne Marie Singh⁴

Affiliations

¹ Division of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA; Division of Allergy and Immunology, Department of Medicine, Northwestern Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA.
² Department of Microbiology-Immunology, Northwestern Feinberg School of Medicine, Northwestern University, Searle Building 3-403, 320 E. Superior Street, Chicago, IL 60611, USA.
³ Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, 730 Welch Rd, Stanford, CA 94305, USA.
⁴ Division of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA; Division of Allergy and Immunology, Department of Medicine, Northwestern Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, #60, Chicago, IL 60611, USA. Electronic address: anne-singh@northwestern.edu.

PMID: 26456445
PMCID: PMC4721650
DOI: 10.1016/j.pcl.2015.07.007

Abstract

The impact of gut microbiome on human development, nutritional needs, and disease has become evident with advances in the ability to study these complex communities of microorganisms, and there is growing appreciation for the role of the microbiome in immune regulation. Several studies have examined associations between changes in the commensal microbiota and the development of asthma, allergic rhinitis, and asthma, but far less have evaluated the impact of the microbiome on the development of food allergy. This article reviews the human gastrointestinal microbiome, focusing on the theory and evidence for its role in the development of IgE-mediated food allergy and other allergic diseases.

Keywords: Allergic disease; Allergic rhinitis; Asthma; Commensal flora; Eczema; Food allergy; Gut microbiota; Microbiome.

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Conflict of interest statement

Conflicts of Interest/Corporate Sponsors: None

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References

1. NIAID-Sponsored Expert Panel, . Boyce JA, Assa’ad A, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. 2010;126:S1–58. doi: 10.1016/j.jaci.2010.10.007. - DOI - PMC - PubMed
1. Sicherer SH, Sampson HA. Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. Journal of Allergy and Clinical Immunology. 2014;133(2):291–307. e5. - PubMed
1. Gupta RS, Springston EE, Warrier MR, et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011;128(1):e9–17. doi: 10.1542/peds.2011-0204. - DOI - PubMed
1. Jackson KD, Howie LD, Akinbami LJ. Trends in allergic conditions among children: United States, 1997–2011. NCHS Data Brief. 2013;(121):1–8. - PubMed
1. Yocum MW, Khan DA. Assessment of patients who have experienced anaphylaxis: a 3-year survey. Mayo Clin Proc. 1994;69(1):16–23. - PubMed

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Gut Microbiome and the Development of Food Allergy and Allergic Disease

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Gut Microbiome and the Development of Food Allergy and Allergic Disease

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