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. 2015 Oct;29(5):301-8.
doi: 10.3341/kjo.2015.29.5.301. Epub 2015 Sep 22.

Factors Affecting Treatment Outcome of Graft Infection Following Penetrating Keratoplasty

Mi Sun Sung  1 , Won Choi  1 , In Cheon You  2 , Kyung Chul Yoon  1
Affiliations

Factors Affecting Treatment Outcome of Graft Infection Following Penetrating Keratoplasty

Mi Sun Sung et al. Korean J Ophthalmol. 2015 Oct.

Abstract

Purpose: To evaluate the factors affecting treatment outcome of graft infection following penetrating keratoplasty (PKP).

Methods: In this retrospective study, 28 patients who underwent PKP between January 2005 and January 2013 and who were diagnosed with graft infection were classified into a treatment success group or a treatment failure group. Demographic and clinical characteristics, as well as the results of the microbiologic investigation, were analyzed and compared. A subsequent binary logistic regression analysis was performed to identify the prognostic factors affecting treatment outcome.

Results: Graft infection occurred at a mean of 38.29 ± 36.16 months (range, 1 to 96 months) after PKP. Seventeen patients developed bacterial keratitis, and 11 patients developed fungal keratitis. Overall, of the 28 patients, nine (32.1%) were classified in the treatment failure group. Multivariate analysis identified pre-existing graft failure (p = 0.019), interval longer than 72 hours between donor death and PKP (p = 0.010), and fungal infection (p = 0.026) as significant risk factors for treatment failure.

Conclusions: Pre-existing graft failure, extended interval between donor death and PKP, and fungal infection were important risk factors for treatment failure of graft infection following PKP.

Keywords: Graft infection; Penetrating keratoplasty; Prognostic factor; Treatment outcome.

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Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Distribution of intervals between penetrating keratoplasty (PKP) and graft infection.
See this image and copyright information in PMC

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