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Review
. 2015:2015:839875.
doi: 10.1155/2015/839875. Epub 2015 Sep 20.

Prevalence of Budd-Chiari Syndrome during Pregnancy or Puerperium: A Systematic Review and Meta-Analysis

Weirong Ren  1 , Xiang Li  2 , Jia Jia  3 , Yan Xia  4 , Fengrong Hu  5 , Zhengyu Xu  1
Affiliations
Review

Prevalence of Budd-Chiari Syndrome during Pregnancy or Puerperium: A Systematic Review and Meta-Analysis

Weirong Ren et al. Gastroenterol Res Pract. 2015.

Abstract

Women during pregnancy or puerperium are likely to develop Budd-Chiari syndrome (BCS). However, the reported prevalence of pregnancy-related BCS varied considerably among studies. Our study aims to systematically review this issue. Overall, 817 papers were initially identified via the PubMed, EMBASE, China National Knowledge Infrastructure, and Chinese Scientific and Technological Journal databases. Twenty of them were eligible. The prevalence of pregnancy-related BCS varied from 0% to 21.5%. The pooled prevalence was 6.8% (95% CI: 3.9-10.5%) in all BCS patients, 6.3% (95% CI: 3.8-9.4%) in primary BCS patients, and 13.1% (95% CI: 7.1-20.7%) in female BCS patients. Among them, one study was carried out in Africa with a prevalence of 10.6%; 14 studies in Asian countries with a pooled prevalence of 7.1% (95% CI: 3.1-12.6%); and 5 studies in European countries with a pooled prevalence of 5.0% (95% CI: 3.1-7.3%). The pooled prevalence was 6.7% (95% CI: 2.6-12.3%) in studies published before 2005 and 7.3% (95% CI: 4.2-12.5%) in those published after 2005. In conclusion, pregnancy is a relatively common risk factor for BCS, but there is a huge variation in the prevalence among studies. Physicians should be aware of pregnancy-related BCS.

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Figures

Figure 1
Figure 1
Flowchart for the literature search. Abbreviations: CNKI, China National Knowledge Infrastructure; VIP, Chinese Scientific and Technological Journal.
Figure 2
Figure 2
Prevalence of pregnancy-related BCS in different countries.
Figure 3
Figure 3
Forest plots of prevalence of pregnancy-related BCS in all included studies (a), female patients (b).
Figure 4
Figure 4
Forest plots of prevalence of pregnancy-related BCS in Asian (a) and European studies (b).
Figure 5
Figure 5
Forest plots of prevalence of pregnancy-related BCS in Indian (a), Chinese (b), and Turkish studies (c).
Figure 6
Figure 6
Forest plots of prevalence of pregnancy-related BCS according to the publication year ((a): before 2005, (b): after 2005).
See this image and copyright information in PMC

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