Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep-Oct;20(5):599-603.
doi: 10.4103/1735-9066.164507.

Effect of Olea ointment and Acetate Mafenide on burn wounds - A randomized clinical trial

Mohsen Zahmatkesh  1 , Mohammad Jalili Manesh  2 , Ronak Babashahabi  3
Affiliations

Effect of Olea ointment and Acetate Mafenide on burn wounds - A randomized clinical trial

Mohsen Zahmatkesh et al. Iran J Nurs Midwifery Res. 2015 Sep-Oct.

Abstract

Background: The main goals in treating burns are to accelerate tissue renovation and prevent infection. Topical antibiotics are used in the treatment of burns, but they can cause side effects. Recently, a traditional ointment (Olea) has been used in Iran in the treatment of burns. This study examines the effect of topical honey ointment in healing of burn patients.

Materials and methods: In this randomized controlled trial (RCT), 30 hospitalized patients selected by conventional sampling (10 in Olea group and 20 in Acetate Mafenide ointment group) were evaluated. Inclusion criteria were: having second-degree burns and body surface area equal to or < 40%. One group was treated using topical Olea ointment and the other with Acetate Mafenide ointment (8.5%). Chi-square, Fisher exact test, and Kaplan-Meier were used. Significance level was considered as P < 0.05.

Results: None of the patients in the Olea group needed surgery for debridement, while in the second group, 13 patients (65%) needed debridement (P = 0.001). In the Olea group, 1 patient (10%) and in the second group, 19 patients (95%) had positive cultures after 7 days (P < 0.001). The mean time of granulation tissue formation in the Olea group was 12 days (10.3-13.6) and in the other group, it was 17 days (13.3-20.6) (P < 0.001).

Conclusions: Olea ointment is a useful treatment for burns, and it can prevent infections, accelerate tissue repair, and facilitate debridement. Therefore, using this ointment is recommended for the treatment of burns.

Keywords: Burns; re-epithelialization; wound healing; wounds and injuries.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Comparing the duration of granulation tissue formation in both groups during the study period. Uninterrupted lines shows Olea group and broken lines indicate Acetate Mafenide group. The mean time of granulation tissue formation in the Olea and Acetate Mafenide groups was 12 days (10.3–13.6) and 17 days (13.3–20.6), respectively (P < 0.001)
See this image and copyright information in PMC

References

    1. Salas Campos L, Fernandes Mansilla M, Martinez de la Chica AM. Topical chemotherapy for the treatment of burns. Rev Enferm. 2005;28:67–70. - PubMed
    1. Wijesinghe M, Weatherall M, Perrin K, Beasley R. Honey in the treatment of burns: A systematic review and meta-analysis of its efficacy. N Z Med J. 2009;122:47–60. - PubMed
    1. Atiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: Review of the literature. Burns. 2007;33:139–48. - PubMed
    1. Poon VK, Burd A. In vitro cytotoxity of silver: Implication for clinical wound care. Burns. 2004;30:140–7. - PubMed
    1. Song JJ, Salcido R. Use of Honey in Wound Care: An Update. Advances in Skin and Wound Care. 2011;24:40–4. - PubMed