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Clinical Trial
. 1989 Mar;146(3):373-6.
doi: 10.1176/ajp.146.3.373.

Doxepin as an adjunct to smoking cessation: a double-blind pilot study

N B Edwards  1 , J K Murphy, A D Downs, B J Ackerman, T L Rosenthal
Affiliations
Clinical Trial

Doxepin as an adjunct to smoking cessation: a double-blind pilot study

N B Edwards et al. Am J Psychiatry. 1989 Mar.

Abstract

In a double-blind study, 19 adults received bedtime doses of either 150 mg of doxepin hydrochloride (N = 9) or placebo (N = 10). After 3 weeks the subjects were instructed to stop smoking and continue taking medication for 4 additional weeks. Cessation was reported by all nine doxepin subjects 1 week after cessation and by seven doxepin subjects 9 weeks after cessation. One placebo subject reported cessation. Cotinine assays generally confirmed cessation but were subject to interpretation. Doxepin assays suggested that the precessation level was associated with cessation. Further studies with larger samples and extended follow-up are needed to determine the reliability of these results.

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Comment in

  • Antidepressants and cessation of smoking.
    Churchill CM, Pariser SF, Larson CN, Dilsaver SC. Churchill CM, et al. Am J Psychiatry. 1989 Sep;146(9):1238-9. doi: 10.1176/ajp.146.9.aj14691238. Am J Psychiatry. 1989. PMID: 2764194 No abstract available.

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