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Observational Study
. 2015 Oct 12:14:139.
doi: 10.1186/s12933-015-0301-5.

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis

Federico Biscetti  1   2 , Giuseppe Straface  3 , Carlo Filippo Porreca  4   5 , Giovanni Bertoletti  6 , Claudio Vincenzoni  7 , Francesco Snider  8 , Egidio Stigliano  9 , Vincenzo Arena  10 , Flavia Angelini  11 , Giovanni Pecorini  12   13 , Antonio Bianchi  14 , Raffaele Landolfi  15 , Andrea Flex  16   17
Affiliations
Observational Study

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis

Federico Biscetti et al. Cardiovasc Diabetol. .

Abstract

Background: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis.

Methods: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis.

Results: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29].

Conclusions: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.

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