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. 2016 Jan;18(1):70-7.
doi: 10.1093/neuonc/nov249. Epub 2015 Oct 12.

Years of potential life lost for brain and CNS tumors relative to other cancers in adults in the United States, 2010

Chaturia Rouse  1 , Haley Gittleman  1 , Quinn T Ostrom  1 , Carol Kruchko  1 , Jill S Barnholtz-Sloan  1
Affiliations

Years of potential life lost for brain and CNS tumors relative to other cancers in adults in the United States, 2010

Chaturia Rouse et al. Neuro Oncol. 2016 Jan.

Abstract

Background: Years of potential life lost (YPLL) complement incidence and survival rates by measuring how much a patient's life is likely to be shortened by his or her cancer. In this study, we examine the impact of death due to brain and other central nervous system (CNS) tumors compared to other common cancers in adults by investigating the YPLL of adults in the United States.

Methods: Mortality and life table data were obtained from the Centers for Disease Control and Prevention's National Center for Health Statistics Vital Statistics Data for 2010. The study population included individuals aged 20 years or older at death who died from one of the selected cancers. YPLL was calculated by taking an individual's age at death and finding the corresponding expected remaining years of life using life table data.

Results: The cancers with the greatest mean YPLL were other malignant CNS tumors (20.65), malignant brain tumors (19.93), and pancreatic cancer (15.13) for males and malignant brain tumors (20.31), breast cancer (18.78), and other malignant CNS tumors (18.36) for females. For both sexes, non-Hispanic whites had the lowest YPLL, followed by non-Hispanic blacks, and Hispanics.

Conclusion: Malignant brain and other CNS tumors have the greatest mean YPLL, thereby reflecting their short survival time post diagnosis. These findings will hopefully motivate more research into mitigating the impact of these debilitating tumors.

Keywords: CBTRUS; NCHS; central nervous system tumors; years of potential life lost.

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Figures

Fig. 1.
Fig. 1.
Incidence rate vs mortality rate for selected cancers.
Fig. 2.
Fig. 2.
Life expectancy by race/ethnicity and sex.
Fig. 3.
Fig. 3.
Age-at-death distributions for selected cancers by race/ethnicity and sex.
Fig. 4.
Fig. 4.
Mean YPLL for selected cancers by race/ethnicity and sex.
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References

    1. Siegel R, Miller K, Jemal A. Cancer statistics, 2015. Ca Cancer J Clin. 2015;65(1):5–29. - PubMed
    1. Heron M. Deaths: leading causes for 2010. Natl Vital Stat Rep. 2013;62(6):1–96. - PubMed
    1. Ostrom QT, Gittleman HR, Liao PL et al. . CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro-Oncology. 2014;16(Suppl 4):iv1–iv63. - PMC - PubMed
    1. Gittleman HR, Ostrom QT, Rouse CD et al. . Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010. Cancer. 2015;121(1):102–112. - PMC - PubMed
    1. Gardner JW, Sanborn JS. Years of potential life lost (YPLL)—what does it measure? Epidemiology. 1990;1(4):322–329. - PubMed

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