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. 2015 Oct 12;60(1):609-12.
doi: 10.1128/AAC.01574-15. Print 2016 Jan.

Preservation of Acquired Colistin Resistance in Gram-Negative Bacteria

Ji-Young Lee  1 , Myung-Jin Choi  1 , Hyeon Jin Choi  1 , Kwan Soo Ko  2
Affiliations

Preservation of Acquired Colistin Resistance in Gram-Negative Bacteria

Ji-Young Lee et al. Antimicrob Agents Chemother. .

Abstract

Colistin-resistant mutants were obtained from 17 colistin-susceptible strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. The stability of colistin resistance in these mutants was investigated. Three of four colistin-resistant P. aeruginosa mutants recovered colistin susceptibility in colistin-free medium; however, colistin-susceptible revertants were obtained from only one strain each of A. baumannii and E. coli. No susceptible revertants were obtained from K. pneumoniae mutants.

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Figures

FIG 1
FIG 1
Change in colistin MIC of resistant mutants obtained by serial passage in colistin-free medium. (A) A. baumannii, (B) P. aeruginosa, (C) K. pneumoniae, and (D) E. coli colistin-resistant mutant strains. The y axis represents the colistin MIC in the log2 scale. Colistin-susceptible revertants were obtained from three P. aeruginosa strains and one strain each of A. baumannii and E. coli resistant mutants. Dashed lines indicate the breakpoint of colistin resistance for each species.
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References

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