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Review
. 2015 Oct:16 Suppl 1:S32-6.
doi: 10.1111/pme.12914.

Opioid Induced Hyperalgesia

Peter Yi  1 , Peter Pryzbylkowski  1
Affiliations
Review

Opioid Induced Hyperalgesia

Peter Yi et al. Pain Med. 2015 Oct.

Abstract

Objective: To discuss the phenomenon of opioid induced hyperalgesia (OIH) and investigate the data and clinical recommendations available on this topic.

Design: A literature search on the topic of OIH was performed. Relevant studies pertaining to OIH were included in this review.

Results: Existing studies and reviews on the pathophysiology, diagnosis, and clinical management of OIH are discussed with updated data and literature references.

Conclusion: As more opioids are prescribed, especially to treat chronic nonmalignant pain, OIH becomes more of a relevant and significant issue. Although the exact mechanisms of OIH are not clearly understood further research is required to broaden and develop our knowledge of this topic.

Keywords: Opioid; Opioid Induced Hyperalgesia.

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