Of Brains and Blood: Developmental Origins of Glioma Diversity?
- PMID: 26461085
- DOI: 10.1016/j.ccell.2015.09.013
Of Brains and Blood: Developmental Origins of Glioma Diversity?
Abstract
The multiple cell types of brain and blood arise from pluripotent stem cells via progressively more committed downstream progenitors. In this issue of Cancer Cell, Alcantara Llaguno and colleagues show that identical genetic drivers give rise to distinct glioma subtypes within differentially committed neural progenitors-a paradigm well established for leukemias.
Copyright © 2015 Elsevier Inc. All rights reserved.
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Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes.Cancer Cell. 2015 Oct 12;28(4):429-440. doi: 10.1016/j.ccell.2015.09.007. Cancer Cell. 2015. PMID: 26461091 Free PMC article.
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