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Comment
. 2015 Oct 12;28(4):405-406.
doi: 10.1016/j.ccell.2015.09.016.

Splicing and Dicing MYC-Mediated Synthetic Lethality

Zachary E Stine  1 , Chi V Dang  2
Affiliations
Free article
Comment

Splicing and Dicing MYC-Mediated Synthetic Lethality

Zachary E Stine et al. Cancer Cell. .
Free article

Abstract

In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.

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  • The spliceosome is a therapeutic vulnerability in MYC-driven cancer.
    Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF. Hsu TY, et al. Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2. Nature. 2015. PMID: 26331541 Free PMC article.

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