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Comment
. 2015 Oct 12;28(4):407-408.
doi: 10.1016/j.ccell.2015.09.019.

The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail?

Christopher G Abraham  1 , Joaquín M Espinosa  2
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The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail?

Christopher G Abraham et al. Cancer Cell. .
Free article

Abstract

Mutations in the TP53 gene not only inactivate its tumor suppressor function but also confer this transcription factor with gain-of-function oncogenic properties. A recent paper by Zhu and colleagues reveals a novel molecular pathway driven by mutant p53 and the COMPASS chromatin-modifying complex that is amenable to pharmacological inhibition.

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