Subtyping Pancreatic Cancer
- PMID: 26461089
- DOI: 10.1016/j.ccell.2015.09.020
Subtyping Pancreatic Cancer
Abstract
The complex tumor microenvironment can make molecularly subtyping cancer using mRNA expression challenging, particularly for cancers with low epithelial content, such as pancreatic cancer. In a recent edition of Nature Genetics, Moffitt and colleagues show that subtracting normal epithelial transcripts can provide insights into the molecular pathology of pancreatic cancer.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma.Nat Genet. 2015 Oct;47(10):1168-78. doi: 10.1038/ng.3398. Epub 2015 Sep 7. Nat Genet. 2015. PMID: 26343385 Free PMC article.
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