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. 2015 Dec 1;6(38):41350-9.
doi: 10.18632/oncotarget.5534.

The prognostic value of peripheral CD4+CD25+ T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion

Qing-Kun Song  1 , Jun Ren  1   2   3 , Xin-Na Zhou  1   2 , Xiao-Li Wang  1   2 , Guo-Hong Song  2 , Li-Jun Di  2 , Jing Yu  2 , Amy Hobeika  3 , Michael A Morse  4 , Yan-Hua Yuan  1 , Hua-Bing Yang  1 , Herbert Kim Lyerly  3
Affiliations

The prognostic value of peripheral CD4+CD25+ T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion

Qing-Kun Song et al. Oncotarget. .

Abstract

Objective: This study aimed to assess the prognostic value of CD4+CD25+ T lymphocyte in peripheral blood among breast cancer patients treated with adoptive T lymphocytes immunotherapy.

Methods: 217 patients participated in the follow-up study. CD4+CD25+ proportion was measured by flow cytometry in peripheral T cells. The median survival was estimated by Kaplan-Meier curve, Log-rank test and Cox hazard proportion regression model, between groups of CD4+CD25+ proportion more than 5% and less than or equal to 5% in peripheral T cells.

Results: Peripheral CD4+CD25+ T lymphocytes had not a relationship with progression-free survival. It was featured that above 5% peripheral CD4+CD25+ proportion of T cells was related with the median overall survival by a shorten of 51 months (p < 0.05) with the HR 1.65 (95%CI 1.04, 2.62). Above 5% CD4+CD25+proportion of T cells produced the HR to be 1.76 (95%CI 1.07, 2.87) In stage 0-II patients, and 3.59 (95%CI 1.05, 12.29) in triple negative breast cancer patients.

Conclusions: Cellular immunity restoration recovered by adoptive T cell infusions which resulted in less proportion of peripheral CD4+CD25+T lymphocytes could be a potential prognostic indicator among early stage and triple negative patients.

Keywords: CD4+CD25+ T lymphocyte; adoptive cell therapy; early stage breast cancer; prognosis; triple negative breast cancer.

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Conflict of interest statement

CONFLICTS OF INTEREST

There are none.

Figures

Figure 1
Figure 1. Effects of CD4+ CD25+ proportion of T cells on survival with 95%CI among BC patients, a. progression-free survival, b. overall survival
Figure 2
Figure 2. Effect of CD4+CD25+proportion of T cells on overall survival with 95%CI among BC patients in stage ≤ II
Figure 3
Figure 3. Effect of CD4+CD25+proportion of T cells on overall survival with 95%CI among TNBC patients
See this image and copyright information in PMC

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