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Meta-Analysis
. 2015 Oct 14:5:15179.
doi: 10.1038/srep15179.

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

Bin Shang  1 , Yao Liu  2 , Shu-juan Jiang  2 , Yi Liu  2
Affiliations
Meta-Analysis

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

Bin Shang et al. Sci Rep. .

Abstract

The prognostic value of FoxP3(+) regulatory T cells (Tregs) in cancer remains controversial. We did a meta-analysis to assess the prognostic effect of FoxP3(+) Treg across different types of cancer and to investigate factors associated with variations in this effect. PubMed, Embase, Cochrane CENTRAL, and Scopus were searched to identify eligible studies. In total, we analyzed 76 articles encompassing 17 types of cancer, and including 15,512 cancer cases. The overall pooled analysis including all types of cancer suggested FoxP3(+)Tregs had a significant negative effect on overall survival (OS) (OR 1.46, P < 0.001), but the prognostic effect varied greatly according to tumor site. High FoxP3(+) Tregs infiltration was significantly associated with shorter OS in the majority of solid tumors studied, including cervical, renal, melanomas, and breast cancers, et al; whereas, FoxP3(+) Tregs were associated with improved survival in colorectal, head and neck, and oesophageal cancers. The stratified analysis suggested the molecular subtype and tumor stage significantly influenced the prognostic value of FoxP3(+) Tregs in certain types of cancer. In conclusion, our meta-analysis suggests that the prognostic role of FoxP3(+) Tregs was highly influenced by tumor site, and was also correlated with the molecular subtype and tumor stage.

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Figures

Figure 1
Figure 1. Flow diagram of search strategy and study selection.
Figure 2
Figure 2. Summary risk estimates of overall survival (OS) by cancer sites.
Figure 3
Figure 3. Summary risk estimates of disease-free survival (DFS) by cancer sites.
See this image and copyright information in PMC

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References

    1. Galon J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 313, 1960–1964 (2006). - PubMed
    1. Leffers N. et al. Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic le.sions of advanced stage ovarian cancer. Cancer Immunol Immunother 58, 449–459 (2009). - PMC - PubMed
    1. Sato E. et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 102, 18538–18543 (2005). - PMC - PubMed
    1. Shen Z. et al. Higher intratumoral infiltrated Foxp3+ Treg numbers and Foxp3+/CD8+ ratio are associated with adverse prognosis in resectable gastric cancer. J Cancer Res Clin Oncol 136, 1585–1595 (2010). - PMC - PubMed
    1. deLeeuw R. J., Kost S. E., Kakal J. A. & Nelson B. H. The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer: a critical review of the literature. Clin Cancer Res 18, 3022–3029 (2012). - PubMed

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