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Meta-Analysis
. 2015 Oct 14:5:15203.
doi: 10.1038/srep15203.

Teeth loss, teeth brushing and esophageal carcinoma: a systematic review and meta-analysis

Hui Chen  1   2 , Shuping Nie  1   2 , Yuhui Zhu  1   2 , Ming Lu  1   2
Affiliations
Meta-Analysis

Teeth loss, teeth brushing and esophageal carcinoma: a systematic review and meta-analysis

Hui Chen et al. Sci Rep. .

Abstract

Esophageal carcinoma (EC) is a serious malignancy, and its epidemiologic etiology is not fully explained. We performed this review to investigate the association between teeth loss and teeth brushing and the risk of EC. A systematic search was conducted to identify all relevant studies. The Q test and I(2) statistic were used to examine between-study heterogeneity. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were considered by fixed or random effects models. Furthermore, we conducted subgroup analyses based on study design, the studies' geographic regions and case type of origin. Modified Egger linear regression test was used to estimate publication bias. Ten articles were included. Pooled analyses indicated that teeth loss was associated with an increased risk of EC for Asians (OR, 1.52; 95% CI: 1.30, 1.78), and high frequency of teeth brushing was associated with a lower incidence of EC (OR, 0.62; 95%CI: 0.43, 0.89). Subgroup analyses showed consistent results and no publication bias existed. Teeth loss and teeth brushing play potential roles in the progressing of EC. People should take care of their oral health in daily life. And large well-designed researches are needed to fully describe the association between teeth health and EC risk.

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Figures

Figure 1
Figure 1. Flow diagram of study selection based on the eligibility criteria.
Figure 2
Figure 2. Forest plot for the association between teeth brushing and esophageal carcinoma risk.
Figure 3
Figure 3. Forest plot for the association between teeth loss and esophageal carcinoma risk.
Figure 4
Figure 4. Funnel plot for the association between teeth brushing and esophageal carcinoma.
Figure 5
Figure 5. Funnel plot for the association between teeth loss and esophageal carcinoma.
See this image and copyright information in PMC

References

    1. Pennathur A., Gibson M. K., Jobe B. A. & Luketich J. D. Oesophageal carcinoma. The Lancet 381, 400–412 (2013). - PubMed
    1. Zhang Y. Epidemiology of esophageal cancer. World J Gastroenterol 19, 5598–5606 (2013). - PMC - PubMed
    1. Tang W. R. et al. Epidemiological characteristics and prediction of esophageal cancer mortality in china from 1991 to 2012. Asian Pac J Cancer Prev 15, 6929–6934 (2014). - PubMed
    1. Mao W. M., Zheng W. H. & Ling Z. Q. Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev 12, 2461–2466 (2011). - PubMed
    1. Chen W. et al. Esophageal cancer incidence and mortality in China, 2009. J Thorac Dis 5, 19–26 (2013). - PMC - PubMed

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