Emerging Technologies for Next-Generation Point-of-Care Testing

doi:10.1016/j.tibtech.2015.09.001

Review

. 2015 Nov;33(11):692-705.

doi: 10.1016/j.tibtech.2015.09.001. Epub 2015 Oct 17.

Emerging Technologies for Next-Generation Point-of-Care Testing

Sandeep Kumar Vashist¹, Peter B Luppa², Leslie Y Yeo³, Aydogan Ozcan⁴, John H T Luong⁵

Affiliations

¹ Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, D-81675 Munich, Germany. Electronic address: sandeep.vashist@tum.de.
² Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, D-81675 Munich, Germany.
³ Micro/Nanophysics Research Laboratory, RMIT University, Melbourne, VIC 3001, Australia.
⁴ Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA; Bioengineering Department, University of California, Los Angeles, CA 90095, USA; California NanoSystems Institute (CNSI), University of California, Los Angeles, CA 90095, USA.
⁵ Innovative Chromatography Group, Irish Separation Science Cluster (ISSC), Department of Chemistry and Analytical, Biological Chemistry Research Facility (ABCRF), University College Cork, Cork, Ireland. Electronic address: j.luong@ucc.ie.

PMID: 26463722
DOI: 10.1016/j.tibtech.2015.09.001

Review

Emerging Technologies for Next-Generation Point-of-Care Testing

Sandeep Kumar Vashist et al. Trends Biotechnol. 2015 Nov.

. 2015 Nov;33(11):692-705.

doi: 10.1016/j.tibtech.2015.09.001. Epub 2015 Oct 17.

Authors

Sandeep Kumar Vashist¹, Peter B Luppa², Leslie Y Yeo³, Aydogan Ozcan⁴, John H T Luong⁵

Affiliations

¹ Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, D-81675 Munich, Germany. Electronic address: sandeep.vashist@tum.de.
² Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, D-81675 Munich, Germany.
³ Micro/Nanophysics Research Laboratory, RMIT University, Melbourne, VIC 3001, Australia.
⁴ Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA; Bioengineering Department, University of California, Los Angeles, CA 90095, USA; California NanoSystems Institute (CNSI), University of California, Los Angeles, CA 90095, USA.
⁵ Innovative Chromatography Group, Irish Separation Science Cluster (ISSC), Department of Chemistry and Analytical, Biological Chemistry Research Facility (ABCRF), University College Cork, Cork, Ireland. Electronic address: j.luong@ucc.ie.

PMID: 26463722
DOI: 10.1016/j.tibtech.2015.09.001

Abstract

Considerable advances in point-of-care testing (POCT) devices stem from innovations in cellphone (CP)-based technologies, paper-based assays (PBAs), lab-on-a-chip (LOC) platforms, novel assay formats, and strategies for long-term reagent storage. Various commercial CP platforms have emerged to provide cost-effective mobile health care and personalized medicine. Such assay formats, as well as low-cost PBAs and LOC-based assays, are paving the way to robust, automated, simplified, and cost-effective POCT. Strategies have also been devised to stabilize reagent storage and usage at ambient temperature. Nevertheless, successful commercialization and widespread implementation of such clinically viable technologies remain subject to several challenges and pending issues.

Keywords: assays; cellphone; lab on a chip; paper; point-of-care testing; reagent storage.

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Emerging Technologies for Next-Generation Point-of-Care Testing

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Emerging Technologies for Next-Generation Point-of-Care Testing

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