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Editorial
. 2015 Oct;110(10):1473-4.
doi: 10.1038/ajg.2015.315.

Clarity and caution in the natural history of low-grade dysplasia in ulcerative colitis

John B Kisiel  1 , Edward V Loftus  1
Affiliations
Editorial

Clarity and caution in the natural history of low-grade dysplasia in ulcerative colitis

John B Kisiel et al. Am J Gastroenterol. 2015 Oct.

Abstract

A substantial body of evidence supports the safety of conservative endoscopic polypectomy for discrete, adenomatous-appearing colonic polyps in patients with ulcerative colitis (UC). Much less is known about the clinicopathologic factors of low-grade dysplastic lesions at risk for subsequent high-grade dysplasia or colorectal cancer. In this issue of the American Journal of Gastroenterology, Choi et al. examine the outcome of patients with low-grade dysplasia participating in a surveillance cohort at St Mark's Hospital, one of the oldest and largest programs of its kind. Long-term follow-up of many, well-phenotyped, low-grade dysplasia cases sheds new light, and raises new questions, on our UC surveillance practice.

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Conflict of interest statement

Potential competing interests: none

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References

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